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Gene expression predicts chemotherapy sensitivity of triple-negative breast...

German researchers have identified an unexpected molecular marker that predicts how sensitive hard-to-treat triple-negative breast cancers are to chemotherapy.

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Glioblastoma multiforme in the Dock

Glioblastoma multiforme (GBM) is the most common malignant brain cancer in humans. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to...

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Breaking oncogene's hold on cancer cell provides new treatment direction

Just as people's bodies and minds can become addicted to substances such as drugs, caffeine, alcohol, their cancers can become addicted to certain genes that insure their continued growth and dominance.

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Study finds two genes affect anxiety, behavior in mice with too much MeCP2

The anxiety and behavioral issues associated with excess MeCP2 protein result from overexpression of two genes (Crh [corticotropin-releasing hormone] and Oprm 1 [mu-opioid receptor MOR 1]), which may...

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Studies help clarify the role of lapatinib and trastuzumab in treating HER2...

In patients with HER2-positive breast cancer, Tykerb (lapatinib) has been used both in combination with herceptin (trastuzumab) and as an alternative single-agent therapy for pre-surgery (neo-adjuvant)...

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New therapeutic target to combat liver cancer discovered

Spanish researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R...

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UK study provides insight into cancer progression

The University of Kentucky has announced that Dr. Daret St. Clair, the James Graham Brown Endowed Chair and professor of toxicology, has published the first comprehensive study that provides insight...

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Researchers identify new regulator in allergic diseases

Researchers have taken a critical step in understanding how allergic reactions occur after identifying a genetic signature for regulation of a key immune hormone, interleukin (IL-13).

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A boost in microRNA may protect against sepsis and other inflammatory diseases

Acute inflammatory diseases, such as sepsis, as well as chronic inflammatory diseases like diabetes and arthritis, develop as a result of sustained inflammation of the blood vessel wall. Researchers at...

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Cutting calories might help you live longer, but not without increased...

Dietary restriction can slow age-related diseases and extend the lifespan of all species tested to date. Understanding this phenomenon might help people live longer, preferably without having to...

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A 'Kit' for increasing insulin production

Scientists from Western University in London, Canada and the Children's Health Research Institute, an Institute within the Lawson Health Research Institute, have identified the critical role of a...

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Researchers find driver of breast cancer stem cell metastasis

The finding involves the cancer gene RhoC, which has previously been shown to promote metastasis of many types of cancer. RhoC levels increase as breast cancer progresses and high levels of RhoC are...

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Congenital disease linked to adipocyte development

(HealthDay)—Some patients with congenital generalized lipodystrophy (CGL), who lack adipocytes and develop severe insulin resistance, have a defect in adipocyte development that can be partially...

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Lack of oxygen in cancer cells leads to growth and metastasis

(Medical Xpress)—It seems as if a tumor deprived of oxygen would shrink. However, numerous studies have shown that tumor hypoxia, in which portions of the tumor have significantly low oxygen...

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Cell surface transporters exploited for cancer drug delivery

Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant...

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Researchers uncover previously unknown mechanism of memory formation

(Medical Xpress)—It takes a lot to make a memory. New proteins have to be synthesized, neuron structures altered. While some of these memory-building mechanisms are known, many are not. Some recent...

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Novel herbal compound offers potential to prevent and treat Alzheimer's disease

Administration of the active compound tetrahydroxystilbene glucoside (TSG) derived from the Chinese herbal medicine Polygonum multiflorum Thunb, reversed both overexpression of α-synuclein, a small...

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Sodium transporter appears likely target for treating salt-sensitive...

Genetics and demographics likely put you at risk for salt-sensitive hypertension, and scientists are looking for a way to protect you.

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Study IDs potential treatment for deadly, HIV-related blood cancer

Researchers at the USC Norris Comprehensive Cancer Center have discovered a promising new way to treat a rare and aggressive blood cancer most commonly found in people infected with HIV.

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New research suggests cutting calories may improve response to cancer treatment

New research suggests that restricting calories for a defined period of time may improve the success of cancer treatment, offering valuable new data on how caloric intake may play a role in programmed...

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